Tenecteplase can cause bleeding that usually is not serious. Also, rate of noncerebral bleeding is less than in alteplase. Hmgcoareductaseinhibitorsstatins pregnancycategoryx indications. The mah subsequently sent a letter to healthcare professionals followed the publication. Full dose tenecteplase tnktpa together with heparin. Effective in producing thrombolysis of a clot involved in a myocardial infarction. Activase is supplied as a sterile, lyophilized powder in 50 mg vials containing vacuum and in 100 mg vials without vacuum. Effient prasugrel dose, indications, adverse effects. Iv tpa administration mgh american heart association. Reperfusion therapy for acute myocardial infarction jason s. Efficacy and safety of two unfractionated heparin dosing. Find a helpful tnkase tenecteplase dosing guidelines chart for acute myocardial infarction treatment with the simple weighttiered tnkase dosing. Find an overview of the activase alteplase dosing guidelines, as well as a stepbystep guide for administering to patients.
Ischemic stroke within 3 months except acute ischemic stroke within 3 patient weight kg tnk mg tnk ml less than 60 kg 30 mg 6 ml 60 or more but less than 70 35 mg 7 ml 70 or more but less than 80 40 mg 8 ml. The recommended total dose should not exceed 50 mg and is based upon. Longer halflife, more rapid thrombolysis, greater fibrin specificity. Two additional reports stated that the prescriptions were verbally ordered as tnk.
Full dose tenecteplase tnktpa together with heparin sodium, full dose tenecteplase with enoxaparin, half dose tenecteplase together with abciximab and heparin sodium in patients with acute myocardial infarction ami full text view. Tenecteplase tnkase a d d r e s s o g r a p h treatment regimen. Tenecteplase tnktpa is a mutated variant of recombinant tissue plasminogen activator. Precipitation may occur when tnkase is administered in an iv line containing dextrose. Dosing and administration for adult patients patient population recommended dosage strength and frequency adultra, as, and psa 50mg weekly. A single bolus dose should be administered over 5 seconds based on patient weight. View the tnkase dosing and administration for ami video. Flush a dextrosecontaining line with a salinecontaining solution prior to and following administration precipitation may occur when tnkase is administered in an iv line containing dextrose. Card valid for 12 consecutive months from activation date. Tenecteplase tnktpa is a third generation thrombolytic agent with advantages over alteplase. Although not as effective as the recommended every 8 week dosing regimen, patients may also be treated with one dose every 12 weeks after one year of effective therapy. Benefits not to exceed program expiration on december 31, 2020. Tnkase tenecteplase dose, indications, adverse effects.
However, serious bleeding may occur in some people. The recommended total dose should not exceed 50 mg and is based upon patient weight. Accaha guidelines for the management of patients with st. Although the complete drug name is tnkase, healthcare professionals sometimes use the shortened abbreviation. Tnkase lyophilisate for solution for injection drug summary. Highlights of prescribing information these highlights do not include all the information needed to use enbrel safely and effectively. Tnkase lyophilisate for solution for injection drug. Heparin may contribute to the bleeding risks associated with tnkase. Tenecteplase is a thrombolytic thrombolitik drug, sometimes called a clotbusting drug. Treatment should be initiated as soon as possible after the onset of ami symptoms see clinical studies. Instruct patient to report hypersensitivity reactions rash, dyspnea and bleedingorbruising.
Each 50 mg activase vial 29 million iu is packaged with diluent for reconstitution 50 ml sterile water for injection, usp. Common and rare side effects for tnkase intravenous. Prescribing and administration guide for intraarterial tenecteplase. Reperfusion therapy for acute myocardial infarction.
Please see full prescribing information for additional important safety information. Indications activase alteplase is indicated for the treatment of acute ischemic stroke. Pdr drug summaries are concise pointofcare prescribing, dosing and administering information to help phsyicans more efficiently and accurately prescribe in their practice pdr s drug summaries are available free of charge and serve as a great resource for us based mds, dos, nps and pas in patient practice. Efficacy and safety of two unfractionated heparin dosing strategies with tenecteplase in acute myocardial infarction results from assessment of the safety and efficacy of a new thrombolytic regimens 2 and 3.
The required dose should be administered as a single intravenous bolus over 5 to 10 seconds. Thrombolytic enzyme pregnancy risk category c action binds to fibrin and converts plasminogen to plasmin, which breaks down fibrin clots and lyses thrombi and emboli. When pump alarms no flow above, there is still some tpa left in the tubing whioch must be infused. Learn more about singlebolus tnkase tenecteplase acute myocardial infarction treatment and the 5second tnkase dosing and administration. Also, move around and be handled as little as possible, and do not get out of bed on your own, unless your health care professional tells you it is all right to do so. Program an infusion pump to deliver the appropriate volume as a bolus at the initiation of the infusion 2. To help prevent serious bleeding, carefully follow any instructions given by your health care professional. Tenecteplase tnkase dosing nd stemi guideline stsegment elevation myocardial infarction updated 072016 7. Ismp s list of confused drug names contains lookalike and soundalike lasa name pairs, of medications that have been published in the ismp medication safety alert.
Exclude intracranial hemorrhage as the primary cause of stroke signs and symptoms prior to initiation. To return damaged product, please contact genentech customer service at 800 5512231. Buy tnkase from any of our recognized mail order pharmacy and enjoy guaranteed. It is available in three doses, 30 mg, 40 mg and 50 mg. Set infusion pump rate according to dosing sheet and start infusion with a total infusion time of 1 hour. Exclude intracranial hemorrhage as the primary cause of stroke signs and symptoms prior to initiation of treatment. Capitals indicate lifethreatening, underlines indicate most frequent.
Find medication information including related drug classes, side effects, patient statistics and answers to frequently asked questions. When genentech product is prescribed for a labeled indication is spoiled and unable to be administered, the product might be eligible for replacement through the genentech spoilage replacement program. Use of an equivalent heparin dose with tpaderived thrombolytics increases bleeding. Find information about common, infrequent and rare side effects of tnkase intravenous. Stemi thrombolysis protocol stelevation mi cree health. Tenecteplase is a 527 amino acid glycoprotein developed by introducing the following modifications to the complementary dna cdna for natural human tpa. Insurance mobile apps goodrx prescription discount card drugs az drugs by health conditions drug classes most prescribed drugs goodrx for pets inside rx goodrx. Learn more about tnkase tenecteplase and the tnkase kit, including tnkase ami treatment, and tnkase dosing instructions for patients. Tenecteplase is a 527 amino acid glycoprotein developed by introducing the following. The safety of the use of tnkase with other antiplatelet agents has not been adequately studied. It helps your body produce a substance that dissolves unwanted blood clots tenecteplase is used to prevent death in people who have had a heart attack acute myocardial infarction tenecteplase may also be used for purposes not listed in this medication guide. Asa 320 mg 4 tabs 80 mg chewed stat unless allergic then ecasa 80 mg qd.
Intramuscular injections and nonessential handling of the patient should be avoided for the first few hours following treatment with tnkase. Tnkase tenecteplase is for intravenous administration only. Download ais resources here, including a stroke assessment card ring, a dosing and administration poster, and more to help supplement your patient care. Acute myocardial infarction preprinted order sheet. Dextrosecontaining lines should be flushed with a salinecontaining solution prior to and following single bolus administration of. The infusion should begin immediately following the bolus. Dosing according to the hero hirulog and early reperfusion or occlusion2 regimen a bolus of 0. Document infusion start time and name of stroke neurologist.
One card per patient, not transferable, and cannot be combined with any other offer. At north drug store, this drug is available as tnkase, a highly sterile, lylophilized powder in 50 mg vials under partial vacuum. Tnkase is a sterile, white to offwhite, lyophilized powder for single intravenous iv bolus administration after reconstitution with sterile water for injection swfi, usp. In massachusetts, the validity of this voucher and its use are subject to changes per state law. Explain need for bedrest and minimal handling during therapy to. Tnkase may be administered as reconstituted at 5 mgml.
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